Pathway candidateNCBI-verifiedprotein-coding

DRD3

dopamine receptor D3

NCBI Gene: 1814 Ensembl GeneCards UniProt: P35462

Pathway candidate — not linked to PFS or PSSD by any record here

DRD3 is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in DRD3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (neurotransmission). Encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Dopamine receptor D3
Function (excerpt): G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure. Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Dopamine receptors can be classified in two categories: (1) DRD3 (together with DRD2 and DRD4) is a D2-type receptor and is coupled to G(i)/G(o) G proteins, mediating inhibition of adenylate cyclase activity, while D1-type receptors (DRD1 and DRD5) are coupled to G(s) G proteins and promote activation of adenylate cyclase activity.
Subcellular location: Cell membrane.
Tissue specificity: Brain.
Associated conditions: Tremor, hereditary essential 1 (ETM1); Schizophrenia (SCZD).

Source: UniProtKB/Swiss-Prot P35462, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for DRD3 specifically.

Mentioned in 0 corpus records

No corpus record names DRD3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

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Protein reference (UniProt)

Protein: Dopamine receptor D3
Function (excerpt): G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure. Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Dopamine receptors can be classified in two categories: (1) DRD3 (together with DRD2 and DRD4) is a D2-type receptor and is coupled to G(i)/G(o) G proteins, mediating inhibition of adenylate cyclase activity, while D1-type receptors (DRD1 and DRD5) are coupled to G(s) G proteins and promote activation of adenylate cyclase activity.
Subcellular location: Cell membrane.
Tissue specificity: Brain.
Associated conditions: Tremor, hereditary essential 1 (ETM1); Schizophrenia (SCZD).