Pathway candidateNCBI-verifiedprotein-coding

GABBR1

gamma-aminobutyric acid type B receptor subunit 1

NCBI Gene: 2550 Ensembl GeneCards UniProt: Q9UBS5

Pathway candidate — not linked to PFS or PSSD by any record here

GABBR1 is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in GABBR1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 6 (neurotransmission). Encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Gamma-aminobutyric acid type B receptor subunit 1
Function (excerpt): Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission.
Subcellular location: Cell membrane; Postsynaptic cell membrane; Cell projection, dendrite; Secreted.
Tissue specificity: Highly expressed in brain. Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer. Isoform 1B: Mainly expressed in Purkinje cells. Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.
Associated conditions: Neurodevelopmental disorder with language delay and variable cognitive abnormalities (NEDLC).

Source: UniProtKB/Swiss-Prot Q9UBS5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for GABBR1 specifically.

Mentioned in 0 corpus records

No corpus record names GABBR1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Gamma-aminobutyric acid type B receptor subunit 1
Function (excerpt): Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission.
Subcellular location: Cell membrane; Postsynaptic cell membrane; Cell projection, dendrite; Secreted.
Tissue specificity: Highly expressed in brain. Weakly expressed in heart, small intestine and uterus. Isoform 1A: Mainly expressed in granular cell and molecular layer. Isoform 1B: Mainly expressed in Purkinje cells. Isoform 1E: Predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.
Associated conditions: Neurodevelopmental disorder with language delay and variable cognitive abnormalities (NEDLC).