Pathway candidateNCBI-verifiedprotein-coding

GATA3

GATA binding protein 3

NCBI Gene: 2625 Ensembl GeneCards UniProt: P23771

Pathway candidate — not linked to PFS or PSSD by any record here

GATA3 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in GATA3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 10 (cell signaling and transcription factors). Encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Trans-acting T-cell-specific transcription factor GATA-3
Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
Subcellular location: Nucleus.
Tissue specificity: T-cells and endothelial cells.
Associated conditions: Hypoparathyroidism, sensorineural deafness, and renal disease (HDR).

Source: UniProtKB/Swiss-Prot P23771, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for GATA3 specifically.

Mentioned in 0 corpus records

No corpus record names GATA3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Trans-acting T-cell-specific transcription factor GATA-3
Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages.
Subcellular location: Nucleus.
Tissue specificity: T-cells and endothelial cells.
Associated conditions: Hypoparathyroidism, sensorineural deafness, and renal disease (HDR).