Pathway candidateNCBI-verifiedprotein-coding

GRIN2A

glutamate ionotropic receptor NMDA type subunit 2A

NCBI Gene: 2903 Ensembl GeneCards UniProt: Q12879

Pathway candidate — not linked to PFS or PSSD by any record here

GRIN2A is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in GRIN2A is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 16 (neurotransmission). Encodes a member of the glutamate-gated ion channel protein family. The protein is an N-methyl-D-aspartate (NMDA) receptor subunit.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Glutamate receptor ionotropic, NMDA 2A
Function (excerpt): Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
Subcellular location: Cell projection, dendritic spine; Cell membrane; Synapse; Postsynaptic cell membrane; Cytoplasmic vesicle membrane.
Associated conditions: Epilepsy, focal, with speech disorder and with or without impaired intellectual development (FESD).

Source: UniProtKB/Swiss-Prot Q12879, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for GRIN2A specifically.

Mentioned in 0 corpus records

No corpus record names GRIN2A directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Glutamate receptor ionotropic, NMDA 2A
Function (excerpt): Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.
Subcellular location: Cell projection, dendritic spine; Cell membrane; Synapse; Postsynaptic cell membrane; Cytoplasmic vesicle membrane.
Associated conditions: Epilepsy, focal, with speech disorder and with or without impaired intellectual development (FESD).