GTF2E1
general transcription factor IIE subunit 1
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 3 (basal transcription machinery). Enables RNA polymerase II general transcription initiation factor activity. Involved in RNA polymerase II preinitiation complex assembly.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
General transcription factor IIE subunit 1
- Function
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
- Subcellular location
Nucleus.
Source: UniProtKB/Swiss-Prot P29083, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Core RNA polymerase II machinery; general cellular function with no direct post-drug-syndrome link established.
Written for the whole basal transcription family, not for GTF2E1 specifically.
Mentioned in 0 corpus records
No corpus record names GTF2E1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Basal transcription).
Also in basal transcription machinery
All 27 genes- GTF2A1
general transcription factor IIA subunit 1
chr 14· Basal transcription· Pathway candidate - GTF2B
general transcription factor IIB
chr 1· Basal transcription· Pathway candidate - GTF2F1
general transcription factor IIF subunit 1
chr 19· Basal transcription· Pathway candidate - GTF2H1
general transcription factor IIH subunit 1
chr 11· Basal transcription· Pathway candidate - POLR2A
RNA polymerase II subunit A
chr 17· Basal transcription· Pathway candidate - POLR2B
RNA polymerase II subunit B
chr 4· Basal transcription· Pathway candidate - POLR2C
RNA polymerase II subunit C
chr 16· Basal transcription· Pathway candidate - POLR2D
RNA polymerase II subunit D
chr 2· Basal transcription· Pathway candidate
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