Pathway candidateNCBI-verifiedprotein-coding

POLR2A

RNA polymerase II subunit A

NCBI Gene: 5430 Ensembl GeneCards UniProt: P24928

Pathway candidate — not linked to PFS or PSSD by any record here

POLR2A is in the library because it belongs to the basal transcription family. No study, report or commentary in the corpus names it, so a variant in POLR2A is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (basal transcription machinery). Encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: DNA-directed RNA polymerase II subunit RPB1
Function (excerpt): Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand.
Subcellular location: Nucleus; Cytoplasm; Chromosome.
Associated conditions: Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities (NEDHIB).

Source: UniProtKB/Swiss-Prot P24928, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Core RNA polymerase II machinery; general cellular function with no direct post-drug-syndrome link established.

Written for the whole basal transcription family, not for POLR2A specifically.

Mentioned in 0 corpus records

No corpus record names POLR2A directly yet. It is in the library because it sits in a pathway the corpus tracks (Basal transcription).

Also in basal transcription machinery

All 27 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: DNA-directed RNA polymerase II subunit RPB1
Function (excerpt): Catalytic core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity). Pol II-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol II pre-initiation complex (PIC) is recruited to DNA promoters, with focused-type promoters containing either the initiator (Inr) element, or the TATA-box found in cell-type specific genes and dispersed-type promoters that often contain hypomethylated CpG islands usually found in housekeeping genes. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand.
Subcellular location: Nucleus; Cytoplasm; Chromosome.
Associated conditions: Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities (NEDHIB).