Pathway candidateNCBI-verifiedprotein-coding

GTF2H1

general transcription factor IIH subunit 1

NCBI Gene: 2965 Ensembl GeneCards UniProt: P32780

Pathway candidate — not linked to PFS or PSSD by any record here

GTF2H1 is in the library because it belongs to the basal transcription family. No study, report or commentary in the corpus names it, so a variant in GTF2H1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (basal transcription machinery). Enables nuclear thyroid hormone receptor binding activity. Involved in positive regulation of DNA-templated transcription and transcription initiation at RNA polymerase II promoter.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: General transcription factor IIH subunit 1
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular location: Nucleus.

Source: UniProtKB/Swiss-Prot P32780, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Core RNA polymerase II machinery; general cellular function with no direct post-drug-syndrome link established.

Written for the whole basal transcription family, not for GTF2H1 specifically.

Mentioned in 0 corpus records

No corpus record names GTF2H1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Basal transcription).

Also in basal transcription machinery

All 27 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: General transcription factor IIH subunit 1
Function: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Subcellular location: Nucleus.