Pathway candidateNCBI-verifiedprotein-coding

HTR1D

5-hydroxytryptamine receptor 1D

NCBI Gene: 3352 Ensembl GeneCards UniProt: P28221

Pathway candidate — not linked to PFS or PSSD by any record here

HTR1D is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in HTR1D is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (neurotransmission). Enables Gi/o-coupled serotonin receptor activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway and intestine smooth muscle contraction.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 1D
Function: G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Subcellular location: Cell membrane.
Tissue specificity: Detected in brain neocortex and caudate nucleus (at protein level).

Source: UniProtKB/Swiss-Prot P28221, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for HTR1D specifically.

Mentioned in 0 corpus records

No corpus record names HTR1D directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

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Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 1D
Function: G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Subcellular location: Cell membrane.
Tissue specificity: Detected in brain neocortex and caudate nucleus (at protein level).