Pathway candidateNCBI-verifiedprotein-coding

HTR1F

5-hydroxytryptamine receptor 1F

NCBI Gene: 3355 Ensembl GeneCards UniProt: P30939

Pathway candidate — not linked to PFS or PSSD by any record here

HTR1F is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in HTR1F is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (neurotransmission). Enables Gi/o-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 1F
Function: G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Receptor for lasmiditan, a drug for the treatment of acute migraine. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity.
Subcellular location: Cell membrane.

Source: UniProtKB/Swiss-Prot P30939, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for HTR1F specifically.

Mentioned in 0 corpus records

No corpus record names HTR1F directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 1F
Function: G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Receptor for lasmiditan, a drug for the treatment of acute migraine. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity.
Subcellular location: Cell membrane.