Pathway candidateNCBI-verifiedprotein-coding

HTR3C

5-hydroxytryptamine receptor 3C

NCBI Gene: 170572 Ensembl GeneCards UniProt: Q8WXA8

Pathway candidate — not linked to PFS or PSSD by any record here

HTR3C is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in HTR3C is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (neurotransmission). The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 3C
Function: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular location: Postsynaptic cell membrane; Cell membrane.
Tissue specificity: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.

Source: UniProtKB/Swiss-Prot Q8WXA8, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for HTR3C specifically.

Mentioned in 0 corpus records

No corpus record names HTR3C directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 3C
Function: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular location: Postsynaptic cell membrane; Cell membrane.
Tissue specificity: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.