Pathway candidateNCBI-verifiedprotein-coding

HTR3D

5-hydroxytryptamine receptor 3D

NCBI Gene: 200909 Ensembl GeneCards UniProt: Q70Z44

Pathway candidate — not linked to PFS or PSSD by any record here

HTR3D is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in HTR3D is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (neurotransmission). The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 3D
Function: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular location: Postsynaptic cell membrane; Cell membrane.
Tissue specificity: Expressed in liver, as well as fetal and adult colon and kidney.

Source: UniProtKB/Swiss-Prot Q70Z44, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for HTR3D specifically.

Mentioned in 0 corpus records

No corpus record names HTR3D directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 3D
Function: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.
Subcellular location: Postsynaptic cell membrane; Cell membrane.
Tissue specificity: Expressed in liver, as well as fetal and adult colon and kidney.