Pathway candidateNCBI-verifiedprotein-coding

HTR6

5-hydroxytryptamine receptor 6

NCBI Gene: 3362 Ensembl GeneCards UniProt: P50406

Pathway candidate — not linked to PFS or PSSD by any record here

HTR6 is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in HTR6 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (neurotransmission). Encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 6
Function: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling.
Subcellular location: Cell membrane.
Tissue specificity: Expressed in several human brain regions, most prominently in the caudate nucleus.

Source: UniProtKB/Swiss-Prot P50406, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for HTR6 specifically.

Mentioned in 0 corpus records

No corpus record names HTR6 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 6
Function: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling.
Subcellular location: Cell membrane.
Tissue specificity: Expressed in several human brain regions, most prominently in the caudate nucleus.