Pathway candidateNCBI-verifiedprotein-coding

HTR7

5-hydroxytryptamine receptor 7

NCBI Gene: 3363 Ensembl GeneCards UniProt: P34969

Pathway candidate — not linked to PFS or PSSD by any record here

HTR7 is in the library because it belongs to the neurotransmission family. No study, report or commentary in the corpus names it, so a variant in HTR7 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 10 (neurotransmission). The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 7
Function: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.
Subcellular location: Cell membrane.
Tissue specificity: Isoform A: Predominant isoform in spleen, caudate and hippocampus. Isoform B: Expressed at lower levels. Isoform D: Minor isoform in terms of expression.

Source: UniProtKB/Swiss-Prot P34969, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).

Written for the whole neurotransmission family, not for HTR7 specifically.

Mentioned in 0 corpus records

No corpus record names HTR7 directly yet. It is in the library because it sits in a pathway the corpus tracks (Neurotransmission).

Also in neurotransmission

All 54 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 5-hydroxytryptamine receptor 7
Function: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.
Subcellular location: Cell membrane.
Tissue specificity: Isoform A: Predominant isoform in spleen, caudate and hippocampus. Isoform B: Expressed at lower levels. Isoform D: Minor isoform in terms of expression.