MAX
MYC associated transcriptional regulator X
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 14 (cell signaling and transcription factors). The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Protein max
- Function
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
- Subcellular location
Nucleus; Cell projection, dendrite.
- Tissue specificity
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
- Associated conditions
Pheochromocytoma (PCC); Polydactyly-macrocephaly syndrome (PDMCS).
Source: UniProtKB/Swiss-Prot P61244, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.
Written for the whole signaling & transcription family, not for MAX specifically.
Mentioned in 0 corpus records
No corpus record names MAX directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).
Also in cell signaling and transcription factors
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clock circadian regulator
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cAMP responsive element binding protein 1
chr 2· Signaling & transcription· Pathway candidate - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - FOXA2
forkhead box A2
chr 20· Signaling & transcription· Pathway candidate - FOXO1
forkhead box O1
chr 13· Signaling & transcription· Pathway candidate - FOXO3
forkhead box O3
chr 6· Signaling & transcription· Pathway candidate - FOXO4
forkhead box O4
chr X· Signaling & transcription· Pathway candidate - GATA2
GATA binding protein 2
chr 3· Signaling & transcription· Pathway candidate
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