Pathway candidateNCBI-verifiedprotein-coding

MED1

mediator complex subunit 1

NCBI Gene: 5469 Ensembl GeneCards UniProt: Q15648

Pathway candidate — not linked to PFS or PSSD by any record here

MED1 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in MED1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (cell signaling and transcription factors). Encodes a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. The protein is also a component of thyroid hormone receptor-associated complexes, regulates p53-dependent apoptosis and is essential for adipogenesis.

Source: NCBI Gene, accessed 2026-10-10; corrected that day, as the page had carried MBD4's record.

Protein reference (UniProt)

Protein: Mediator of RNA polymerase II transcription subunit 1
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitously expressed.

Source: UniProtKB/Swiss-Prot Q15648, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for MED1 specifically.

Mentioned in 0 corpus records

No corpus record names MED1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-10; corrected that day, as the page had carried MBD4's record.

Protein reference (UniProt)

Protein: Mediator of RNA polymerase II transcription subunit 1
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitously expressed.