Pathway candidateNCBI-verifiedprotein-coding

MED12

mediator complex subunit 12

NCBI Gene: 9968 Ensembl GeneCards UniProt: Q93074

Pathway candidate — not linked to PFS or PSSD by any record here

MED12 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in MED12 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (cell signaling and transcription factors). The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mediator of RNA polymerase II transcription subunit 12
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitous.
Associated conditions: Opitz-Kaveggia syndrome (OKS); Intellectual developmental disorder, X-linked, syndromic, Lujan-Fryns type (MRXSLF); Ohdo syndrome, X-linked (OHDOX); Hardikar syndrome (HDKR).

Source: UniProtKB/Swiss-Prot Q93074, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for MED12 specifically.

Mentioned in 0 corpus records

No corpus record names MED12 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mediator of RNA polymerase II transcription subunit 12
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitous.
Associated conditions: Opitz-Kaveggia syndrome (OKS); Intellectual developmental disorder, X-linked, syndromic, Lujan-Fryns type (MRXSLF); Ohdo syndrome, X-linked (OHDOX); Hardikar syndrome (HDKR).