Pathway candidateNCBI-verifiedprotein-coding

MED13

mediator complex subunit 13

NCBI Gene: 9969 Ensembl GeneCards UniProt: Q9UHV7

Pathway candidate — not linked to PFS or PSSD by any record here

MED13 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in MED13 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (cell signaling and transcription factors). Encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mediator of RNA polymerase II transcription subunit 13
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitous.
Associated conditions: Intellectual developmental disorder, autosomal dominant 61 (MRD61).

Source: UniProtKB/Swiss-Prot Q9UHV7, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for MED13 specifically.

Mentioned in 0 corpus records

No corpus record names MED13 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mediator of RNA polymerase II transcription subunit 13
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus.
Tissue specificity: Ubiquitous.
Associated conditions: Intellectual developmental disorder, autosomal dominant 61 (MRD61).