Pathway candidateNCBI-verifiedprotein-coding

MED16

mediator complex subunit 16

NCBI Gene: 10025 Ensembl GeneCards UniProt: Q9Y2X0

Pathway candidate — not linked to PFS or PSSD by any record here

MED16 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in MED16 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 19 (cell signaling and transcription factors). Enables nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation by RNA polymerase II.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mediator of RNA polymerase II transcription subunit 16
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus.
Associated conditions: Guillouet-Gordon syndrome (GGNS).

Source: UniProtKB/Swiss-Prot Q9Y2X0, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for MED16 specifically.

Mentioned in 0 corpus records

No corpus record names MED16 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Mediator of RNA polymerase II transcription subunit 16
Function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular location: Nucleus.
Associated conditions: Guillouet-Gordon syndrome (GGNS).