MYCN
MYCN proto-oncogene, bHLH transcription factor
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 2 (cell signaling and transcription factors). This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
N-myc proto-oncogene protein
- Function
Positively regulates the transcription of MYCNOS in neuroblastoma cells.
- Subcellular location
Nucleus.
- Tissue specificity
Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).
- Associated conditions
Feingold syndrome 1 (FGLDS1); Megalencephaly-polydactyly syndrome (MPAPA).
Source: UniProtKB/Swiss-Prot P04198, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.
Written for the whole signaling & transcription family, not for MYCN specifically.
Mentioned in 0 corpus records
No corpus record names MYCN directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).
Also in cell signaling and transcription factors
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clock circadian regulator
chr 4· Signaling & transcription· Pathway candidate - CREB1
cAMP responsive element binding protein 1
chr 2· Signaling & transcription· Pathway candidate - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - FOXA2
forkhead box A2
chr 20· Signaling & transcription· Pathway candidate - FOXO1
forkhead box O1
chr 13· Signaling & transcription· Pathway candidate - FOXO3
forkhead box O3
chr 6· Signaling & transcription· Pathway candidate - FOXO4
forkhead box O4
chr X· Signaling & transcription· Pathway candidate - GATA2
GATA binding protein 2
chr 3· Signaling & transcription· Pathway candidate
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