Pathway candidateNCBI-verifiedprotein-coding

PAX5

paired box 5

NCBI Gene: 5079 Ensembl GeneCards UniProt: Q02548

Pathway candidate — not linked to PFS or PSSD by any record here

PAX5 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in PAX5 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 9 (cell signaling and transcription factors). Encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Paired box protein Pax-5
Function: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire.
Subcellular location: Nucleus.
Associated conditions: Leukemia, acute lymphoblastic, 3 (ALL3).

Source: UniProtKB/Swiss-Prot Q02548, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for PAX5 specifically.

Mentioned in 0 corpus records

No corpus record names PAX5 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Paired box protein Pax-5
Function: Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire.
Subcellular location: Nucleus.
Associated conditions: Leukemia, acute lymphoblastic, 3 (ALL3).