Pathway candidateNCBI-verifiedprotein-coding

PIAS1

protein inhibitor of activated STAT 1

NCBI Gene: 8554 Ensembl GeneCards UniProt: O75925

Pathway candidate — not linked to PFS or PSSD by any record here

PIAS1 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in PIAS1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 15 (cell signaling and transcription factors). Encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: E3 SUMO-protein ligase PIAS1
Function (excerpt): Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2, PML and ZNF76. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection. Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity).
Pathway: Protein modification; protein sumoylation.
Subcellular location: Nucleus; Nucleus speckle; Nucleus, PML body; Cytoplasm, cytoskeleton.
Tissue specificity: Expressed in numerous tissues with highest level in testis.

Source: UniProtKB/Swiss-Prot O75925, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for PIAS1 specifically.

Mentioned in 0 corpus records

No corpus record names PIAS1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: E3 SUMO-protein ligase PIAS1
Function (excerpt): Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Catalyzes sumoylation of various proteins, such as CEBPB, MRE11, MTA1, PTK2, PML and ZNF76. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Mediates sumoylation of MRE11, stabilizing MRE11 on chromatin during end resection. Sumoylates PML (at 'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation (By similarity). PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity).
Pathway: Protein modification; protein sumoylation.
Subcellular location: Nucleus; Nucleus speckle; Nucleus, PML body; Cytoplasm, cytoskeleton.
Tissue specificity: Expressed in numerous tissues with highest level in testis.