PTGES3
prostaglandin E synthase 3
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 12 (steroid receptor chaperones). Encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Prostaglandin E synthase 3
- Function
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
- Pathway
Lipid metabolism; prostaglandin biosynthesis.
- Subcellular location
Cytoplasm.
Source: UniProtKB/Swiss-Prot Q15185, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Chaperone/co-chaperone control of steroid-receptor folding and sensitivity is a regulatory layer above the receptors themselves, tied to stress-axis signaling.
Written for the whole receptor chaperones family, not for PTGES3 specifically.
Mentioned in 0 corpus records
No corpus record names PTGES3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Receptor chaperones).
Also in steroid receptor chaperones
All 14 genes- BAG1
BAG cochaperone 1
chr 9· Receptor chaperones· Pathway candidate - BAG3
BAG cochaperone 3
chr 10· Receptor chaperones· Pathway candidate - FKBP4
FKBP prolyl isomerase 4
chr 12· Receptor chaperones· Pathway candidate - FKBP5
FKBP prolyl isomerase 5
chr 6· Receptor chaperones· Pathway candidate - FKBP6
FKBP prolyl isomerase family member 6 (inactive)
chr 7· Receptor chaperones· Pathway candidate - HSP90AA1
heat shock protein 90 alpha family class A member 1
chr 14· Receptor chaperones· Pathway candidate - HSP90AB1
heat shock protein 90 alpha family class B member 1
chr 6· Receptor chaperones· Pathway candidate - HSPD1
heat shock protein family D (Hsp60) member 1
chr 2· Receptor chaperones· Pathway candidate
Browse by family on the gene families page.