Pathway candidateNCBI-verifiedprotein-coding

RELB

RELB proto-oncogene, NF-kB subunit

NCBI Gene: 5971 Ensembl GeneCards UniProt: Q01201

Pathway candidate — not linked to PFS or PSSD by any record here

RELB is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in RELB is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 19 (cell signaling and transcription factors). Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Transcription factor RelB
Function (excerpt): NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors.
Subcellular location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Associated conditions: Immunodeficiency 53 (IMD53).

Source: UniProtKB/Swiss-Prot Q01201, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for RELB specifically.

Mentioned in 0 corpus records

No corpus record names RELB directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Transcription factor RelB
Function (excerpt): NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors.
Subcellular location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Associated conditions: Immunodeficiency 53 (IMD53).