Pathway candidateNCBI-verifiedprotein-coding

RNF4

ring finger protein 4

NCBI Gene: 6047 Ensembl GeneCards UniProt: P78317

Pathway candidate — not linked to PFS or PSSD by any record here

RNF4 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in RNF4 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 4 (cell signaling and transcription factors). The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: E3 ubiquitin-protein ligase RNF4
Function: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97.
Pathway: Protein modification; protein ubiquitination.
Subcellular location: Cytoplasm; Nucleus; Nucleus, PML body.
Tissue specificity: Widely expressed at low levels in many tissues; highly expressed in testis.

Source: UniProtKB/Swiss-Prot P78317, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for RNF4 specifically.

Mentioned in 0 corpus records

No corpus record names RNF4 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

All 52 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: E3 ubiquitin-protein ligase RNF4
Function: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97.
Pathway: Protein modification; protein ubiquitination.
Subcellular location: Cytoplasm; Nucleus; Nucleus, PML body.
Tissue specificity: Widely expressed at low levels in many tissues; highly expressed in testis.