SMAD7
SMAD family member 7
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 18 (cell signaling and transcription factors). The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
SMAD family member 7
- Function
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
- Subcellular location
Nucleus; Cytoplasm.
- Tissue specificity
Ubiquitous with higher expression in the lung and vascular endothelium.
- Associated conditions
Colorectal cancer 3 (CRCS3).
Source: UniProtKB/Swiss-Prot O15105, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.
Written for the whole signaling & transcription family, not for SMAD7 specifically.
Mentioned in 0 corpus records
No corpus record names SMAD7 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).
Also in cell signaling and transcription factors
All 52 genes- CLOCK
clock circadian regulator
chr 4· Signaling & transcription· Pathway candidate - CREB1
cAMP responsive element binding protein 1
chr 2· Signaling & transcription· Pathway candidate - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - FOXA2
forkhead box A2
chr 20· Signaling & transcription· Pathway candidate - FOXO1
forkhead box O1
chr 13· Signaling & transcription· Pathway candidate - FOXO3
forkhead box O3
chr 6· Signaling & transcription· Pathway candidate - FOXO4
forkhead box O4
chr X· Signaling & transcription· Pathway candidate - GATA2
GATA binding protein 2
chr 3· Signaling & transcription· Pathway candidate
Browse by family on the gene families page.