SOX2
SRY-box transcription factor 2
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 3 (cell signaling and transcription factors). This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Transcription factor SOX-2
- Function
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
- Subcellular location
Nucleus speckle; Cytoplasm; Nucleus.
- Associated conditions
Microphthalmia, syndromic, 3 (MCOPS3).
Source: UniProtKB/Swiss-Prot P48431, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.
Written for the whole signaling & transcription family, not for SOX2 specifically.
Mentioned in 0 corpus records
No corpus record names SOX2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).
Also in cell signaling and transcription factors
All 52 genes- CLOCK
clock circadian regulator
chr 4· Signaling & transcription· Pathway candidate - CREB1
cAMP responsive element binding protein 1
chr 2· Signaling & transcription· Pathway candidate - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - FOXA2
forkhead box A2
chr 20· Signaling & transcription· Pathway candidate - FOXO1
forkhead box O1
chr 13· Signaling & transcription· Pathway candidate - FOXO3
forkhead box O3
chr 6· Signaling & transcription· Pathway candidate - FOXO4
forkhead box O4
chr X· Signaling & transcription· Pathway candidate - GATA2
GATA binding protein 2
chr 3· Signaling & transcription· Pathway candidate
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