STIP1
stress induced phosphoprotein 1
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 11 (steroid receptor chaperones). STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Stress-induced-phosphoprotein 1
- Function
Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
- Subcellular location
Cytoplasm; Nucleus; Dynein axonemal particle.
Source: UniProtKB/Swiss-Prot P31948, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Chaperone/co-chaperone control of steroid-receptor folding and sensitivity is a regulatory layer above the receptors themselves, tied to stress-axis signaling.
Written for the whole receptor chaperones family, not for STIP1 specifically.
Mentioned in 0 corpus records
No corpus record names STIP1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Receptor chaperones).
Also in steroid receptor chaperones
All 14 genes- BAG1
BAG cochaperone 1
chr 9· Receptor chaperones· Pathway candidate - BAG3
BAG cochaperone 3
chr 10· Receptor chaperones· Pathway candidate - FKBP4
FKBP prolyl isomerase 4
chr 12· Receptor chaperones· Pathway candidate - FKBP5
FKBP prolyl isomerase 5
chr 6· Receptor chaperones· Pathway candidate - FKBP6
FKBP prolyl isomerase family member 6 (inactive)
chr 7· Receptor chaperones· Pathway candidate - HSP90AA1
heat shock protein 90 alpha family class A member 1
chr 14· Receptor chaperones· Pathway candidate - HSP90AB1
heat shock protein 90 alpha family class B member 1
chr 6· Receptor chaperones· Pathway candidate - HSPD1
heat shock protein family D (Hsp60) member 1
chr 2· Receptor chaperones· Pathway candidate
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