Pathway candidateNCBI-verifiedprotein-coding

WWTR1

WW domain containing transcription regulator 1

NCBI Gene: 25937 Ensembl GeneCards UniProt: Q9GZV5

Pathway candidate — not linked to PFS or PSSD by any record here

WWTR1 is in the library because it belongs to the signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in WWTR1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 3 (cell signaling and transcription factors). Enables transcription coactivator activity. Involved in several processes, including intracellular signal transduction; negative regulation of canonical Wnt signaling pathway; and positive regulation of cell differentiation.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: WW domain-containing transcription regulator protein 1
Function: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Subcellular location: Nucleus; Cytoplasm; Cell membrane; Cell junction, tight junction.
Tissue specificity: Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.

Source: UniProtKB/Swiss-Prot Q9GZV5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole signaling & transcription family, not for WWTR1 specifically.

Mentioned in 0 corpus records

No corpus record names WWTR1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Signaling & transcription).

Also in cell signaling and transcription factors

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: WW domain-containing transcription regulator protein 1
Function: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Subcellular location: Nucleus; Cytoplasm; Cell membrane; Cell junction, tight junction.
Tissue specificity: Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue.