Analysis of the finasteride treatment and its withdrawal in the rat hypothalamus and hippocampus at whole-transcriptome level
S Giatti, L Cioffi, S Diviccaro, R Piazza, R C Melcangi
Journal of Endocrinological Investigation2024
Summary (paraphrased)
Whole-transcriptome (RNA-seq) analysis of hypothalamus and hippocampus in adult male rats treated with finasteride for 20 days and examined 24 h after last dose and 1 month after withdrawal. Treatment altered 186 genes in hypothalamus and 19 in hippocampus; differential expression was no longer detectable at withdrawal, though gene-set enrichment signals persisted at both time points. Dysregulated genes (TTR, DIO2, CLDN1/2, SLC4A5, KCNE2, CROT, HCRT, MARCKSL1, VGF, IRF2BPL) were mapped onto clinical side effects such as depression, anxiety, memory/attention disturbance, and sleep disruption.
Why it’s in the corpus
Core PFS mechanistic paper: genome-wide brain transcriptome after finasteride and its withdrawal, directly feeding the corpus's gene-expression and neurosteroid-dysregulation tracks. NOTE: discord label 'CYP2D and drug metabolism' is incorrect; PMID 38493246 is this Melcangi-group finasteride study.
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