PIEZO2

Source: NCBI Gene, accessed 2026-10-07.

Protein

Piezo-type mechanosensitive ion channel component 2

Function (excerpt)

Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain. Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways. Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (By similarity). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (By similarity). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (By similarity).

Subcellular location

Cell membrane.

Associated conditions

Arthrogryposis, distal, 5 (DA5); Arthrogryposis, distal, 3 (DA3); Marden-Walker syndrome (MWKS); Arthrogryposis, distal, with impaired proprioception and touch (DAIPT).

Source: UniProtKB/Swiss-Prot Q9H5I5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Written for the whole sensory & ion channels family, not for PIEZO2 specifically.