Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis
Diviccaro, Silvia; Giatti, Silvia; Cioffi, Lucia; Falvo, E.; Caruso, Donatella; Melcangi, Roberto Cosimo
Psychoneuroendocrinology · 1322021
Abstract (paraphrased)
In adult male rats, paroxetine treatment and its withdrawal altered neurosteroid synthesis pathways, showing SSRIs directly perturb neurosteroidogenesis beyond their serotonergic action.
Plain-language summary (paraphrased)
In lab rats, the antidepressant paroxetine disrupted the brain's steroid-making machinery — and the disruption didn't simply reverse when the drug stopped. This is the animal-model counterpart to the human PFS neurosteroid findings, and it shows SSRIs hit the same biological pathway finasteride does.
Why it’s in the corpus
Preclinical proof that SSRIs disrupt neurosteroidogenesis; the direct pharmacological bridge between SSRI action and the PFS neurosteroid mechanism.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Peer-reviewed paper
Paroxetine effects in adult male rat colon: Focus on steroidogenesis and microbiota
Diviccaro, Silvia; Giatti, Silvia; Cioffi, Lucia; Falvo, E.; Piazza, R.; Caruso, Donatella; Melcangi, Roberto Cosimo · Psychoneuroendocrinology · 143
Paroxetine altered steroid synthesis and microbiota composition in rat colon, linking SSRI exposure to gut-steroid disruption relevant to the gut-brain axis.
PSSD-0112022PFSPSSDCore corpus - Peer-reviewed paperSIDEfxHUB pick
Post-Finasteride Syndrome And Post-SSRI Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Giatti, Silvia; Diviccaro, Silvia; Cioffi, Lucia; Melcangi, Roberto Cosimo · Frontiers in Neuroendocrinology · 72
Argues PFS and PSSD share overlapping clinical features (sexual dysfunction, psychological complaints, sleep disorders) and likely common mechanisms involving neuroactive steroids, serotonin/dopamine/catecholamine signaling and gut microbiota, possibly…
PFS-0032024PFSPSSDCore corpus - Peer-reviewed paperPSSD Discord pick
Post-SSRI Sexual Dysfunction (PSSD): A comprehensive review of epidemiology, pathophysiology, and clinical management
Xie, M.; Huang, P.; Wang, S.; Ma, J.; Zeng, Y.; Sun, J. · Journal (SAGE; 2026)
Systematic review (PubMed/Web of Science/Scopus to April 2024) finding persistent symptoms in up to 74% of affected cohorts beyond 6 months; pathophysiology multifactorial — 5-HT1A desensitization, neurosteroid (allopregnanolone) depletion via 5α-reductase…
HTR1APSSD-0032026PFSPSSDCore corpus