Epigenetic Modulation of ESR1 and DNMT3A Following Finasteride Exposure: Implications for Female Reproductive Function
Churchill Jonadab Ihentuge
Physiology (Physiology Summit meeting abstract)2026
Summary (paraphrased)
Conference abstract reporting epigenetic modulation of ESR1 (estrogen receptor alpha) and DNMT3A (DNA methyltransferase 3A — part of the epigenetic machinery itself) following finasteride exposure, framed around female reproductive function. Finasteride perturbing a DNA methyltransferase implies second-order epigenetic effects.
Why it’s in the corpus
DNMT3A modulation is the most mechanistically suggestive item here: if a 5-ARI alters a DNA methyltransferase, the epigenetic footprint can propagate beyond the initial exposure. Also the only female-reproduction framing in the epigenetics set — relevant to post-drug syndromes beyond the male PFS literature.
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