Methylated CpG dinucleotides in the 5-alpha reductase 2 gene may explain finasteride resistance in benign prostatic enlargement patients
Zhemin Lin, Dongdong Fan, Song Jin, Zhanliang Liu, Yi-Nong Niu
Asian Journal of Andrology2021
Summary (paraphrased)
Finds methylated CpG dinucleotides in the SRD5A2 gene and proposes that methylation status of the 5-alpha-reductase-2 gene explains variable finasteride response in benign prostatic enlargement patients. DNA methylation at the very locus encoding finasteride's drug target modulates pharmacodynamics.
Why it’s in the corpus
Ties DNA methylation at SRD5A2 to 5-ARI action in humans — complements the Melcangi 2019 finding of altered SRD5A2 methylation in PFS cerebrospinal fluid (DISC-025) and the SRD5A1 epigenetic-regulation precedent (LIT-058). Methylation at the drug-target locus is a candidate persistence mechanism.
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SRD5A1SRD5A2SRD5A3PFS-0112025Core corpus