Post-Drug Syndromes: A Neglected Challenge in Pharmacovigilance and Public Health
Varun S. Nair
Zenodo2025
Venue reputation unverified
Summary (paraphrased)
This self-published policy brief argues that post-drug syndromes — persistent, multisystem conditions triggered by prescription drugs and continuing long after discontinuation, including PFS, PSSD, and post-retinoid syndromes — are a structurally neglected category of adverse drug reactions. It contends that current pharmacovigilance systems are built to catch acute, temporally proximate events and therefore miss long-latency, persistent harms, despite growing patient-reported evidence and selective regulatory acknowledgments. The brief is framed for public-health and pharmacovigilance audiences rather than as a clinical study.
Why it’s in the corpus
The only item in this sweep that frames persistent post-drug syndromes as a systems problem in pharmacovigilance — directly supports the corpus's "persistent post-drug syndromes generally" axis and gives the advocacy/policy angle a citable anchor.
Related records
- Video
Dr. Will Powers Interview [PFS / PAS / PSSD Summit 2026]
Dr. Will Powers · SIDEfxHUB · unavailable via text fetch
In this summit interview, Dr Will Powers discusses his theory of how post-drug syndromes (PFS, PAS, PSSD) arise, in conversation with SIDEfxHUB's Robb. The interview was recorded at the 2026 PFS/PAS/PSSD summit and covers both his impressions of the event and…
TALK-iWFDBRTgT3g2026PFSPSSDPRSDCore corpus - Video
Dr. Will Powers Interview [PFS / PAS / PSSD Summit 2026]
Dr. Will Powers · SIDEfxHUB - PFS & PSSD Patient Organisation · 21:27 (1287s)
PFS, PAS, PSSD mechanism theory; Powers' unifying model; vulnerability screening
ARARID1ACHD8HDAC10YT-iWFDBRTgT3g2026-04-29PFSPSSDPRSDCore corpus - Peer-reviewed paper
Insights into the peripheral nature of persistent sexual dysfunction associated with post-finasteride, post-SSRI and post-accutane syndromes: lessons learned from a case study
Jackson Stachelek; Bernadette M. M. Zwaans; Roni Mintz Shtein; Kenneth M. Peters · International Urology and Nephrology
The paper frames persistent sexual dysfunction after finasteride/saw palmetto, SSRIs, and retinoids as a single post-drug syndrome of unknown mechanism with no effective treatment, and asks whether targeting the peripheral genital nerves can help. Three men…
LIT-0402025PFSPSSDPRSDLiterature sweep · Oct 2026