Post-SSRI Sexual Dysfunction (PSSD): A comprehensive review of epidemiology, pathophysiology, and clinical management
Xie, M.; Huang, P.; Wang, S.; Ma, J.; Zeng, Y.; Sun, J.
Journal (SAGE; 2026)2026
Abstract (paraphrased)
Systematic review (PubMed/Web of Science/Scopus to April 2024) finding persistent symptoms in up to 74% of affected cohorts beyond 6 months; pathophysiology multifactorial — 5-HT1A desensitization, neurosteroid (allopregnanolone) depletion via 5α-reductase inhibition, epigenetic silencing of dopaminergic reward circuits; diagnosis per 2022 criteria.
Plain-language summary (paraphrased)
The most up-to-date comprehensive PSSD review. Strikingly, it identifies the exact same pathways implicated in PFS: depleted allopregnanolone through 5-alpha-reductase inhibition and epigenetic silencing of pleasure circuits. It also notes symptoms can emerge or worsen after stopping the drug, and that no approved treatment exists.
Why it’s in the corpus
Newest synthesis; explicitly connects SSRIs to the 5α-reductase/neurosteroid pathway — the single strongest pharmacological bridge between PSSD and PFS in the corpus.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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