Re: You know pssd and pfs may actually be the same…
u/drwillpowers
r/DrWillPowers2026-03-24T00:22:39Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Replying to reports of corticosteroid and potassium-iodide windows, Powers theorizes that potassium iodide affects transporters relevant to his model; that thyroid upregulates UGT activity; and that iodine feeds sulfation — one of the last clearance routes when glucuronidation is down. He notes glucocorticoid/androgen-receptor cross-talk and a possible ACTH→CRH/α-MSH rebound libido effect — but classifies all of these as temporary "window" solutions, not fixes. He adds a growing realization: even achieving the correct configuration may not hold if the epigenetic flags cannot be reset.
Key points (paraphrased)
- Iodine/sulfation positioned as backup clearance when glucuronidation is down.
- Thyroid upregulates UGT activity; iodide affects relevant transporters.
- ACTH→CRH/α-MSH rebound proposed as a possible libido-window mechanism.
- Windows vs fixes: all such interventions are temporary without epigenetic reset.
- Pairs with PRH-1515 (the formal window/crash definitions).
Why it’s in the corpus
Sulfation as backup clearance and the pharmacology of windows — why corticosteroids, ACTH and iodide produce transient improvements. Pairs with PRH-1515's canonical definitions.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who reported near-total windows on corticosteroids and ACTH analogs (anhedonia, emotional numbness, blank mind all lifting) and megadose potassium iodide improving PFS-group members, in the PFS/PSSD-sameness data thread.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Powers · Reddit commentCurated Powers pick
Re: You know pssd and pfs may actually be the same…
u/drwillpowers · r/DrWillPowers
Powers gives his canonical definitions: windows happen when something clears enough metabolite load that androgens can reach the receptor again; crashes happen when something slows that clearance. Patients are stuck in a configuration they would normally…
PRH-15152026-03-25T23:33:21ZPFSPSSDPowers Reddit history