Re: You know pssd and pfs may actually be the same…
u/drwillpowers
r/DrWillPowers2026-04-09T14:39:58Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Powers reports that every PFS genome he has examined matches his theory — including one case he initially thought was an exception, until re-review found the missed defect. He also describes reviewing five anonymized SIDEfxHUB patient lab collections, finding the same class of defects in all five, with an important nuance: some were inverse patterns of others (e.g., one case with extremely high urinary androgens while other pathways were suppressed). The common thread, he says, is broken baseline androgen metabolism; finasteride is the overload that collapses the system.
Key points (paraphrased)
- Claims 100% genome–theory concordance, including a re-examined apparent exception.
- Five anonymized SIDEfxHUB lab collections all showed the same class of defects.
- Inverse patterns exist (e.g., very high urinary androgens vs. suppressed pathways) — heterogeneity within the model.
- Common thread: broken baseline androgen metabolism; finasteride as the collapsing overload.
Why it’s in the corpus
An independent-lab corroboration claim via SIDEfxHUB collections. The inverse-pattern nuance matters for the multi-phenotype framework and guards against over-narrow diagnostic criteria that would miss inverted cases.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to a now-deleted comment by u/Drwillpowers himself in his "PSSD and PFS may actually be the same thing" data-request thread; the parent comment's text is unrecoverable.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
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