Re: You know pssd and pfs may actually be the same…
u/drwillpowers
r/DrWillPowers2026-03-25T23:33:21Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Powers gives his canonical definitions: windows happen when something clears enough metabolite load that androgens can reach the receptor again; crashes happen when something slows that clearance. Patients are stuck in a configuration they would normally re-adapt out of, blocked by a still-undiscovered epigenetic-reprogramming anomaly that he hoped to hunt for in PFS genomes.
Key points (paraphrased)
- Window defined as metabolite clearance sufficient for androgen-receptor signaling to resume.
- Crash defined as anything slowing that clearance.
- Stuck configuration attributed to an undiscovered epigenetic-reprogramming anomaly.
- Genome-hunting planned to identify the anomaly.
Why it’s in the corpus
The canonical definitions of windows and crashes — the reference point for all window/crash discussion in the corpus. Pairs with PRH-1514's window pharmacology.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who reported that an arginine/ornithine experience genuinely reduced symptoms — not a placebo effect, not a cure — in the PFS/PSSD-sameness data thread.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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