Re: Anyone out there with pfspssdpostdrug who has…
u/drwillpowers
r/DrWillPowers2026-08-12T16:00:55Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Replying to concerns about trying the castration protocol with severe osteoporosis and soft-tissue problems, Powers states the conundrum plainly: if a month of chemical castration restores normal androgen signaling in someone effectively castrated for a decade, that's smart, not dangerous — but if the osteoporosis stems from something other than poor hormones, removing hormones worsens it. Since finasteride-linked osteoporosis is not an established phenomenon in medicine, he would want near-absolute confidence before acting against the grain.
Key points (paraphrased)
- Conditional safety logic: castration-trial risk depends on the true cause of the bone loss.
- Finasteride-linked osteoporosis is not an established phenomenon — diagnostic caution required.
- Near-absolute confidence required before against-the-grain interventions.
- Illustrates his risk-calibration stance on experimental protocols.
Why it’s in the corpus
Relugolix-trial safety reasoning in its most explicit form. Documents his diagnostic-caution stance: establish the cause before removing hormones, especially where the drug link is unestablished.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who described severe soft-tissue issues and lower lumbar arthritis with declining quality of life and an upcoming MRI, and worried the theory and treatment could be dangerous for their case, in Powers' osteoporosis/hypermobility survey thread.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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