Identification of a novel off-target of paroxetine: Possible role in sexual dysfunction induced by this SSRI antidepressant drug
Giatti, Silvia; Di Domizio, A.; Diviccaro, Silvia; Cioffi, Lucia; Marmorini, I.; Falvo, E.; Caruso, Donatella; Contini, A.; Melcangi, Roberto Cosimo
Journal of Molecular Structure · 12682022
Abstract (paraphrased)
Using in silico screening plus in vitro/in vivo assays, identified a novel protein off-target of paroxetine that may contribute to SSRI-induced sexual dysfunction, expanding the pharmacology beyond serotonin reuptake inhibition.
Plain-language summary (paraphrased)
Using computer modeling and lab tests, researchers found paroxetine binds to an unexpected protein target that could help explain its sexual side effects. It shows SSRIs do more in the body than just raise serotonin — supporting the idea that persistent effects come from these "off-target" actions.
Why it’s in the corpus
Expands SSRI pharmacology beyond the serotonin hypothesis; relevant to why effects can persist and why they're not reversed by simply restoring serotonin.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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