DRD1

Source: NCBI Gene, accessed 2026-10-07.

Protein

Dopamine receptor D1

Function (excerpt)

G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure. Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Dopamine receptors can be classified in two categories: (1) DRD1 (together with DRD5) is a D1-type receptor and is coupled to G(s) G proteins, mediating activation of adenylate cyclase activity, while D2-type receptors (DRD2, DRD3 and DRD4) are coupled to G(i)/G(o) G proteins and promote inhibition of adenylate cyclase activity.

Subcellular location

Postsynaptic cell membrane; Cell projection, dendritic spine membrane; Cell projection, cilium membrane; Endoplasmic reticulum membrane.

Tissue specificity

Detected in caudate, nucleus accumbens and in the olfactory tubercle.

Source: UniProtKB/Swiss-Prot P21728, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Written for the whole neurotransmission family, not for DRD1 specifically.