Paroxetine-induced dopamine dysregulation: insights into the pathogenesis of post-SSRI sexual dysfunction (PSSD)
S Giatti, G Chrostek, L Cioffi, S Diviccaro, F Sanna, R C Melcangi
The Journal of Sexual Medicine2025
Summary (paraphrased)
Congress abstract (J Sex Med Vol 22, Suppl 2, May 2025) extending the Melcangi group's paroxetine work into dopamine signaling: adult male rats treated with paroxetine for 14 days showed significantly reduced dopamine in nucleus accumbens both 24 h after dosing and after 1 month of suspension. qPCR showed elevated MAO-A during treatment and altered TH, VMAT2, DRD1, and DRD2 expression during suspension, suggesting lasting dopaminergic remodeling in a motivation/sexual-behavior circuit.
Why it’s in the corpus
PSSD-relevant conference abstract-only report (peer-reviewed venue, abstract only — not a full paper) linking paroxetine withdrawal to persistent dopamine dysregulation in the nucleus accumbens, a sexual-motivation hub.
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