Pathway candidateNCBI-verifiedprotein-coding

DHRS3

dehydrogenase/reductase 3

NCBI Gene: 9249 Ensembl GeneCards UniProt: O75911

Pathway candidate — not linked to PFS or PSSD by any record here

DHRS3 is in the library because it belongs to the retinoid signaling family. No study, report or commentary in the corpus names it, so a variant in DHRS3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (retinoid signaling). Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification.

Source: NCBI Gene and Ensembl, accessed 2026-10-11.

Protein reference (UniProt)

Protein: Short-chain dehydrogenase/reductase 3
Function: Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. It limits excessive synthesis of all-trans retinoic acid (RA) from all-trans-retinal.
Subcellular location: Membrane.
Tissue specificity: Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
Associated conditions: Craniosynostosis-scoliosis syndrome (CRSS).

Source: UniProtKB/Swiss-Prot O75911, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

These proteins take vitamin A from blood to gene regulation: RBP4 carries retinol, STRA6 takes it into cells, LRAT stores it, RDH10 and the ALDH1A enzymes turn it into retinoic acid (DHRS3 reverses the first step), CRABP2 carries retinoic acid to the nucleus, the RAR and RXR receptors act on it, and CYP26A1 and CYP26B1 break it down. Isotretinoin, the drug behind post-retinoid sexual dysfunction, is a retinoid; and several retinol dehydrogenases (RDH16, HSD17B6, RDH5) also oxidize androgen metabolites such as 3α-androstanediol, a point of contact with the steroid pathways implicated in PFS.

Written for the whole retinoid signaling family, not for DHRS3 specifically.

Mentioned in 0 corpus records

No corpus record names DHRS3 directly yet. It is in the library because it sits in a pathway the corpus tracks (retinoid signaling).

Also in retinoid signaling

All 23 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene and Ensembl, accessed 2026-10-11.

Protein reference (UniProt)

Protein: Short-chain dehydrogenase/reductase 3
Function: Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. It limits excessive synthesis of all-trans retinoic acid (RA) from all-trans-retinal.
Subcellular location: Membrane.
Tissue specificity: Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments.
Associated conditions: Craniosynostosis-scoliosis syndrome (CRSS).

Why its pathway is in the library

Written for the whole retinoid signaling family, not for DHRS3 specifically.