ALDH1A3
aldehyde dehydrogenase 1 family member A3
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 15 (retinoid signaling). This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants.
Source: NCBI Gene and Ensembl, accessed 2026-10-11.
Protein reference (UniProt)
- Protein
Retinaldehyde dehydrogenase 3
- Function
Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity. Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity).
- Pathway
Cofactor metabolism; retinol metabolism.
- Subcellular location
Cytoplasm.
- Tissue specificity
Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
- Associated conditions
Microphthalmia, isolated, 8 (MCOP8).
Source: UniProtKB/Swiss-Prot P47895, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
These proteins take vitamin A from blood to gene regulation: RBP4 carries retinol, STRA6 takes it into cells, LRAT stores it, RDH10 and the ALDH1A enzymes turn it into retinoic acid (DHRS3 reverses the first step), CRABP2 carries retinoic acid to the nucleus, the RAR and RXR receptors act on it, and CYP26A1 and CYP26B1 break it down. Isotretinoin, the drug behind post-retinoid sexual dysfunction, is a retinoid; and several retinol dehydrogenases (RDH16, HSD17B6, RDH5) also oxidize androgen metabolites such as 3α-androstanediol, a point of contact with the steroid pathways implicated in PFS.
Written for the whole retinoid signaling family, not for ALDH1A3 specifically.
Mentioned in 0 corpus records
No corpus record names ALDH1A3 directly yet. It is in the library because it sits in a pathway the corpus tracks (retinoid signaling).
Also in retinoid signaling
All 23 genes- AKR1C3Powers
aldo-keto reductase family 1 member C3
chr 10· Steroid synthesis· 9 records - ALDH1A1
aldehyde dehydrogenase 1 family member A1
chr 9· Drug metabolism· Pathway candidate - ALDH1A2
aldehyde dehydrogenase 1 family member A2
chr 15· Drug metabolism· Pathway candidate - CRABP2
cellular retinoic acid binding protein 2
chr 1· retinoid signaling· Pathway candidate - CYP26A1
cytochrome P450 family 26 subfamily A member 1
chr 10· retinoid signaling· Pathway candidate - CYP26B1
cytochrome P450 family 26 subfamily B member 1
chr 2· retinoid signaling· Pathway candidate - CYP2C8
cytochrome P450 family 2 subfamily C member 8
chr 10· retinoid signaling· Pathway candidate - DHRS3
dehydrogenase/reductase 3
chr 1· retinoid signaling· Pathway candidate
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