Pathway candidateNCBI-verifiedprotein-coding

DICER1

dicer 1, ribonuclease III

NCBI Gene: 23405 Ensembl GeneCards UniProt: Q9UPY3

Pathway candidate — not linked to PFS or PSSD by any record here

DICER1 is in the library because it belongs to the rna processing family. No study, report or commentary in the corpus names it, so a variant in DICER1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 14 (rna processing and mirna biogenesis). Encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Endoribonuclease Dicer
Function: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
Subcellular location: Cytoplasm; Cytoplasm, perinuclear region.
Associated conditions: Pleuropulmonary blastoma (PPB); Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1); Rhabdomyosarcoma, embryonal, 2 (RMSE2); Global developmental delay, lung cysts, overgrowth, and Wilms tumor (GLOW).

Source: UniProtKB/Swiss-Prot Q9UPY3, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

miRNA biogenesis and RNA handling; epigenetic-adjacent regulation with no direct post-drug-syndrome link established.

Written for the whole rna processing family, not for DICER1 specifically.

Mentioned in 0 corpus records

No corpus record names DICER1 directly yet. It is in the library because it sits in a pathway the corpus tracks (RNA processing).

Also in rna processing and mirna biogenesis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Endoribonuclease Dicer
Function: Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.
Subcellular location: Cytoplasm; Cytoplasm, perinuclear region.
Associated conditions: Pleuropulmonary blastoma (PPB); Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1); Rhabdomyosarcoma, embryonal, 2 (RMSE2); Global developmental delay, lung cysts, overgrowth, and Wilms tumor (GLOW).