Pathway candidateNCBI-verifiedprotein-coding

HNRNPK

heterogeneous nuclear ribonucleoprotein K

NCBI Gene: 3190 Ensembl GeneCards UniProt: P61978

Pathway candidate — not linked to PFS or PSSD by any record here

HNRNPK is in the library because it belongs to the rna processing family. No study, report or commentary in the corpus names it, so a variant in HNRNPK is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 9 (rna processing and mirna biogenesis). This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Heterogeneous nuclear ribonucleoprotein K
Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.
Subcellular location: Cytoplasm; Nucleus, nucleoplasm; Cell projection, podosome.
Associated conditions: Au-Kline syndrome (AUKS).

Source: UniProtKB/Swiss-Prot P61978, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

miRNA biogenesis and RNA handling; epigenetic-adjacent regulation with no direct post-drug-syndrome link established.

Written for the whole rna processing family, not for HNRNPK specifically.

Mentioned in 0 corpus records

No corpus record names HNRNPK directly yet. It is in the library because it sits in a pathway the corpus tracks (RNA processing).

Also in rna processing and mirna biogenesis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Heterogeneous nuclear ribonucleoprotein K
Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.
Subcellular location: Cytoplasm; Nucleus, nucleoplasm; Cell projection, podosome.
Associated conditions: Au-Kline syndrome (AUKS).