Pathway candidateNCBI-verifiedprotein-coding

LIN28A

lin-28 RNA binding posttranscriptional regulator A

NCBI Gene: 79727 Ensembl GeneCards UniProt: Q9H9Z2

Pathway candidate — not linked to PFS or PSSD by any record here

LIN28A is in the library because it belongs to the rna processing family. No study, report or commentary in the corpus names it, so a variant in LIN28A is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (rna processing and mirna biogenesis). Encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Protein lin-28 homolog A
Function (excerpt): RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c.
Subcellular location: Cytoplasm; Rough endoplasmic reticulum; Cytoplasm, P-body; Cytoplasm, Stress granule; Nucleus, nucleolus.
Tissue specificity: Expressed in embryonic stem cells, placenta and testis. Tends to be up-regulated in HER2-overexpressing breast tumors.

Source: UniProtKB/Swiss-Prot Q9H9Z2, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

miRNA biogenesis and RNA handling; epigenetic-adjacent regulation with no direct post-drug-syndrome link established.

Written for the whole rna processing family, not for LIN28A specifically.

Mentioned in 0 corpus records

No corpus record names LIN28A directly yet. It is in the library because it sits in a pathway the corpus tracks (RNA processing).

Also in rna processing and mirna biogenesis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Protein lin-28 homolog A
Function (excerpt): RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c.
Subcellular location: Cytoplasm; Rough endoplasmic reticulum; Cytoplasm, P-body; Cytoplasm, Stress granule; Nucleus, nucleolus.
Tissue specificity: Expressed in embryonic stem cells, placenta and testis. Tends to be up-regulated in HER2-overexpressing breast tumors.