Pathway candidateNCBI-verifiedprotein-coding

HNRNPU

heterogeneous nuclear ribonucleoprotein U

NCBI Gene: 3192 Ensembl GeneCards UniProt: Q00839

Pathway candidate — not linked to PFS or PSSD by any record here

HNRNPU is in the library because it belongs to the rna processing family. No study, report or commentary in the corpus names it, so a variant in HNRNPU is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (rna processing and mirna biogenesis). Encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Heterogeneous nuclear ribonucleoprotein U
Function (excerpt): DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator. Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner.
Subcellular location: Nucleus; Nucleus matrix; Chromosome; Nucleus speckle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, spindle pole; Midbody; Cytoplasm; Cell surface; Cytoplasmic granule.
Tissue specificity: Widely expressed.
Associated conditions: Developmental and epileptic encephalopathy 54 (DEE54).

Source: UniProtKB/Swiss-Prot Q00839, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

miRNA biogenesis and RNA handling; epigenetic-adjacent regulation with no direct post-drug-syndrome link established.

Written for the whole rna processing family, not for HNRNPU specifically.

Mentioned in 0 corpus records

No corpus record names HNRNPU directly yet. It is in the library because it sits in a pathway the corpus tracks (RNA processing).

Also in rna processing and mirna biogenesis

All 11 genes

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Heterogeneous nuclear ribonucleoprotein U
Function (excerpt): DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localization of the long non-coding Xist RNA on the inactive chromosome X (Xi) and the subsequent initiation and maintenance of X-linked transcriptional gene silencing during X-inactivation (By similarity). Plays a role as a RNA polymerase II (Pol II) holoenzyme transcription regulator. Promotes transcription initiation by direct association with the core-TFIIH basal transcription factor complex for the assembly of a functional pre-initiation complex with Pol II in a actin-dependent manner.
Subcellular location: Nucleus; Nucleus matrix; Chromosome; Nucleus speckle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Cytoplasm, cytoskeleton, spindle; Cytoplasm, cytoskeleton, spindle pole; Midbody; Cytoplasm; Cell surface; Cytoplasmic granule.
Tissue specificity: Widely expressed.
Associated conditions: Developmental and epileptic encephalopathy 54 (DEE54).