Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 14 (steroid and nuclear hormone receptors). Encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Estrogen receptor beta
- Function
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
- Subcellular location
Nucleus.
- Tissue specificity
Isoform 1: Expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform 2: Expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform 4: Expressed in the testis. Isoform 5: Expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform 6: Expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
- Associated conditions
Ovarian dysgenesis 8 (ODG8).
Source: UniProtKB/Swiss-Prot Q92731, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure.
Written for the whole nuclear receptors family, not for ESR2 specifically.
Mentioned in 0 corpus records
No corpus record names ESR2 directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors).
Also in steroid and nuclear hormone receptors
All 41 genes- ARPowers
androgen receptor
chr X· Nuclear receptors· 41 records - ESR1
estrogen receptor 1
chr 6· Nuclear receptors· 1 record - FOXA1
forkhead box A1
chr 14· Nuclear receptors· Pathway candidate - HNF4A
hepatocyte nuclear factor 4 alpha
chr 20· Nuclear receptors· Pathway candidate - HNF4G
hepatocyte nuclear factor 4 gamma
chr 8· Nuclear receptors· Pathway candidate - NCOA1
nuclear receptor coactivator 1
chr 2· Nuclear receptors· Pathway candidate - NCOA2
nuclear receptor coactivator 2
chr 8· Nuclear receptors· Pathway candidate - NCOA3
nuclear receptor coactivator 3
chr 20· Nuclear receptors· Pathway candidate
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