Pathway candidateNCBI-verifiedprotein-coding

HNF4A

hepatocyte nuclear factor 4 alpha

Chromosome 20Nuclear receptors Signaling & transcription

NCBI Gene: 3172 Ensembl GeneCards UniProt: P41235

Pathway candidate — not linked to PFS or PSSD by any record here

HNF4A is in the library because it belongs to the nuclear receptors / signaling & transcription family. No study, report or commentary in the corpus names it, so a variant in HNF4A is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 20 (steroid and nuclear hormone receptors, cell signaling and transcription factors). The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Hepatocyte nuclear factor 4-alpha
Function: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells.
Subcellular location: Nucleus.
Associated conditions: Maturity-onset diabetes of the young 1 (MODY1); Type 2 diabetes mellitus (T2D); Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young (FRTS4).

Source: UniProtKB/Swiss-Prot P41235, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nuclear receptors transduce steroid signals into lasting gene-expression programs; persistent receptor-level remodeling (or silencing) is a leading hypothesis for symptoms that outlast drug exposure. General signaling/transcription machinery; no direct post-drug-syndrome link established for most members — included for completeness of the panel.

Written for the whole nuclear receptors / signaling & transcription family, not for HNF4A specifically.

Mentioned in 0 corpus records

No corpus record names HNF4A directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear receptors, Signaling & transcription).

Also in steroid and nuclear hormone receptors

All 41 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Hepatocyte nuclear factor 4-alpha
Function: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes. Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells.
Subcellular location: Nucleus.
Associated conditions: Maturity-onset diabetes of the young 1 (MODY1); Type 2 diabetes mellitus (T2D); Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young (FRTS4).

Why its pathway is in the library

Written for the whole nuclear receptors / signaling & transcription family, not for HNF4A specifically.